The Possible Preventive Effect of Thymoquinone on the Hematological Picture in Rabbits in which Colorectal Cancer Was Developed Experimentally

الملخص

The aim of this research is to study the potential protective effect of thymoquinone of plant origin on the levels of both red blood cells and white blood cells and platelets in rabbits with colorectal cancer.

This study was conducted on (36) male rabbits of a domestic breed and at the age of (6-4) months, with an average weight of (1400-1200)g, divided into three groups, each of which includes (12)rabbits, the study groups except the first group (passive control) injected two doses of azoxymethane to induce colorectal tumors, by injection into the peritoneal cavity at a dose of (15mg/kg), with an interval of a week between the two doses, i.e. a dose every week, after completion of the injection of azoxymethane, Group II (G2) thymoquinone was administered orally at a dose of (50mg/kg) per day until the end of the trial, group III (positive control) was left untreated throughout the study period. Blood samples for hematological tests were taken on the first day of the experiment, after completion of the injection of azoxymethane, and on the last day of the experiment.

Results: the results of the study of hematological parameters showed. Statistically significant moral increase (P<0.05), both in the carcinoembryonic antigen (CEA), and white blood cells and platelets, and a decrease in the level of red blood cells, are in the third group when compared with the first Group (negative control) and the second group.

Conclusion: dosing thymoquinone orally at a dose of (50 mg/ kg) per day until the end of the experiment, significantly contributed to a significant and statistically significant decrease (P<0.05), in the values of the carcinoembryonic antigen (CEA), And white blood cells and platelets significantly raise the level of red blood cells, and this indicates its role in preventing the effect of the carcinogenic drug on the studied hematological indicators.