The effect of fentanyl on Clinical Symptoms and Hemato- Biochemical Parameters in Dogs

الملخص

The Present study was designed to evaluate the  effect  of  fentanyl on some blood parameters and note some vital reflexes(Heart rate ,analgesia, absence of sensory reflexes ,respiratory rate and temperature degree)which are shown by dogs during injection and after injection. For this purpose ,six dogs with no breed of about  7-9 kg body weight and Aged between 3-4 years where blood samples were taken before injection  then injected intravenously with fentanyl after that  blood samples were taken after 15,30,60,120 minutes and after 24 hour. Then sensory reflexes are  recorded according  to previous intervals. As a result , heart rate ,respiratory rate showed significant decrease (P<0.05)  at time 15,30 minutes while, no significant changes of body temperature after administration.                                                            

 The hematological Parameters Hb ,PCV, blood platelets and RBC showed significant decrease (P<0.05) after injection of fentanyl at time 30,60 minutes while, no significant  changes of White blood cell̦̦̦̦s                                                                                                    

 There were significant  decrease (P<0.05) in serum enzymatic activities of (ALT,AST, CPK, ALP , GGT)  at time15,30. 60 minutes after administration. Sodium and Potassium showed a significant decrease (P<0.05)  at time 15,30 minutes. No significant changes  in concentrations of Calcium ,   Chloride and Magnesium .                                                                                     

Albumin  showed significant decrease (P<0.05)  at time 15,30 minutes while Glucose  showed significant  increase at that time but  creatinine showed significant  decrease at time 15,30 and 60.