الملخص
This study was conducted on ( 24 ) adult rabbits, and aimed to know the effect of different concentrations of sulfaquinoxaline ( 50-100 ) mg/kg on the kidney tissue of rabbits. ( 4 ) groups were used, where each group included (6) rabbits, the first group was left. As a natural control, while the other groups were dosed with sulfaquinoxaline, the first group was given food and water only (control), while the second group was given sulfaquinoxaline at a dose of ( 50 ) mg/kg, the third group was given a dose of ( 100 ) mg/kg of sulfaquinoxaline, and the fourth group was given a dose of ( 100 ) mg/kg of sulfaquinoxaline, then an oral dose of sodium bicarbonate for two consecutive days at a dose of ( 100 ) mg/kg of body weight. The results showed the presence of histological changes represented by the presence of expansion of Bowman's capsule, and atrophy of the glomeruli, in rabbits treated with different doses of sulfaquinoxaline ( 100-50 ) mg / kg body weight, compared with the control group.
References
1. Alonso, .V, Linares, .V, Bellés, .M,. (2009). Sulfaquinoxaline induced oxidative stress: a possible mechanism of male infertility. Reprod Toxicol.;27:35–40.
2. Amine ,B.,& Tarek ,K.,& Riad , B.,& Soumia ,R.,& Ibtessem , L.,& Nadji ,B. (2020).Evaluation of Adverse Effects of Antibiotics on Broiler Chickens .J. World Poult. Res. 10(2S) pp: 145-150.
3. Bani-Asadi ,F.Z.,& Ahmadi ,M.,& Rokni ,N.,& Golestan , L.,& Shahidi ,S. A.(2021). Assessment of the Distribution and Concentration of Residual Antibiotics in Chicken Meat and Liver Samples Collected in Tehran by Liquid Chromatography and Tandem Mass Spectrometry. E JVS, 52,pp: 11-21.
4. Begent ,L.A.,& Hill ,A.R.,& Steventon ,G.B.,& Hutt ,A.J.,& Pallister ,C.J.,& Cowell ,D.C. (2001).Characterization and purification of the vitamin K .epoxide reductasessystemfrom rat liver. J. Phann. PharmacoL: pp 481-486 .
5. Chapman, H.D. (2009). A landmark contribution to poultry science prophylactic control of coccidiosis in poultry. Poult Sci 88:813–815.
6. Doustar,Y.A.,&Feizi,D.,&Mohajeri,M.H.,&Khayat-Nouri,M.H.,&Mohammad,M.H.(2008). Histopathological evaluation of the effect of Sulfamide Trimethoprim administration on renal.Islamic Azad University, Tabriz Branch, Tabriz, Iran tissue in broiler chickens .
7. Duquette, P. (2005). A US perspective on the current and future regulation of anticoccidial drugs and vaccines, Proceedings of the IXth International Coccidiosis Conference . Foz de Iguassu:Parana, Brazil, pp: 117-124.
8. Faddoul , G . P.,& Amato , S. V.,& Sevoian , M. (1966). Studies on Intolerance to Sulfaquinoxaline in Chickens University of Massachusetts, Waltham, Massachusetts . Fellows Avian Diseases, Vol. 11, No. 2. Pp. 226-240.
9. Heidari, .R, Esmailie, .N, Azarpira, .N,. (2016). Effect of thiol-reducing agents and antioxidants on sulfaquinoxaline-induced hepatic injury in normotermic recirculating isolated perfused rat Kedney. Toxicol Res. 2016;32:133–140.
10. Kannan, .K, Jain, S.K. (2000). Oxidative stress and apoptosis. Pathophysiology.;7:153–163.
11. Luna, L. G. (Ed.). (1968). Manual of histologic methods of the armed forces institute of pathology. McGraw-Hill, 36-95.
12. Mor ,F.,& Kocasari ,F. S.,& Ozdemir ,G. B. (2012). Determination of Sulfonamide residues in cattle meats by the Charm-II system and validation with high performance liquid chromatography with fluorescence detection. Food Chemistry. 134, pp: 1645-1649.
13. Odigie, B.E. (2013). Edo State Histological effects of pre-exposure prophylactic consumption of sulfa drugs on Liver and Kidney of albino Wister rats . Benin City: Journal of Pharmacy and Biological Sciences PP 14-19.
14. Preusch ,P.C.,& Hazelett ,S.E.,& Lemasters , K.K. (1989).Sulfaquinoxaline inhibition of vitamin K epoxide and quinone reductase. Arch. Biochem. Biophys. 269. Pp :18-24 .
15. Ronald, A. (2003).The Etiology of Urinary tract infection: traditional and emerging pathogens, Disease-a-Month, 49(2) pp:71-82.
16. Russinko, P.J., Agarwal, S., Choi. M,J,, (2003). Obstructive nephropathy secondary to sulfaquinoxaline calculi. Urology.;62:748.
17. Salem ,D. A.,& Mahmoud ,A. Z.,& Ibrahim ,Th. A.,& Abd El-Naser , M.,& Eman , E. (2000). evaluation of prolonged administration of sulfaquinoxaline on the hepatorenal performance of broiler chickens with special reference to tissue. Univ. Bull. Environ. Res. Vol. 3 No. 1:pp 2-22.
18. Shao, B.,& Dong, D.,& Wu, Y., Hu, J.,& Meng, J.,& Tu, X.,& Xu, S. (2005). Simultaneous determination of 17 sulfonamide residues in porcine meat, kidney and liver by solid-phase extraction and liquid chromatography– tandem mass spectrometry. Analytica Chimica Acta546: pp :174-181.
19. Singh, G. N., (2017). A Review on Drug Induced Hepatotoxicity and Its Management By Herbal Drugs. World J. Pharmacy an Pharmaceut. Sci. 6(8), 446–471.
20. Varagic ,V. M.,& Milosevic ,M. P. (2009). Farmakologija, Elitmedica, Beograd, , pp. 622-627.
21. Well, G.A.H.; Hebert, C.N. and Robins, B.C. (2003). Renal cysts in pigs prevalence and pathology in slaughtered pigs from a single herd. Vet. Rec. 106: 532-635 .
2. Amine ,B.,& Tarek ,K.,& Riad , B.,& Soumia ,R.,& Ibtessem , L.,& Nadji ,B. (2020).Evaluation of Adverse Effects of Antibiotics on Broiler Chickens .J. World Poult. Res. 10(2S) pp: 145-150.
3. Bani-Asadi ,F.Z.,& Ahmadi ,M.,& Rokni ,N.,& Golestan , L.,& Shahidi ,S. A.(2021). Assessment of the Distribution and Concentration of Residual Antibiotics in Chicken Meat and Liver Samples Collected in Tehran by Liquid Chromatography and Tandem Mass Spectrometry. E JVS, 52,pp: 11-21.
4. Begent ,L.A.,& Hill ,A.R.,& Steventon ,G.B.,& Hutt ,A.J.,& Pallister ,C.J.,& Cowell ,D.C. (2001).Characterization and purification of the vitamin K .epoxide reductasessystemfrom rat liver. J. Phann. PharmacoL: pp 481-486 .
5. Chapman, H.D. (2009). A landmark contribution to poultry science prophylactic control of coccidiosis in poultry. Poult Sci 88:813–815.
6. Doustar,Y.A.,&Feizi,D.,&Mohajeri,M.H.,&Khayat-Nouri,M.H.,&Mohammad,M.H.(2008). Histopathological evaluation of the effect of Sulfamide Trimethoprim administration on renal.Islamic Azad University, Tabriz Branch, Tabriz, Iran tissue in broiler chickens .
7. Duquette, P. (2005). A US perspective on the current and future regulation of anticoccidial drugs and vaccines, Proceedings of the IXth International Coccidiosis Conference . Foz de Iguassu:Parana, Brazil, pp: 117-124.
8. Faddoul , G . P.,& Amato , S. V.,& Sevoian , M. (1966). Studies on Intolerance to Sulfaquinoxaline in Chickens University of Massachusetts, Waltham, Massachusetts . Fellows Avian Diseases, Vol. 11, No. 2. Pp. 226-240.
9. Heidari, .R, Esmailie, .N, Azarpira, .N,. (2016). Effect of thiol-reducing agents and antioxidants on sulfaquinoxaline-induced hepatic injury in normotermic recirculating isolated perfused rat Kedney. Toxicol Res. 2016;32:133–140.
10. Kannan, .K, Jain, S.K. (2000). Oxidative stress and apoptosis. Pathophysiology.;7:153–163.
11. Luna, L. G. (Ed.). (1968). Manual of histologic methods of the armed forces institute of pathology. McGraw-Hill, 36-95.
12. Mor ,F.,& Kocasari ,F. S.,& Ozdemir ,G. B. (2012). Determination of Sulfonamide residues in cattle meats by the Charm-II system and validation with high performance liquid chromatography with fluorescence detection. Food Chemistry. 134, pp: 1645-1649.
13. Odigie, B.E. (2013). Edo State Histological effects of pre-exposure prophylactic consumption of sulfa drugs on Liver and Kidney of albino Wister rats . Benin City: Journal of Pharmacy and Biological Sciences PP 14-19.
14. Preusch ,P.C.,& Hazelett ,S.E.,& Lemasters , K.K. (1989).Sulfaquinoxaline inhibition of vitamin K epoxide and quinone reductase. Arch. Biochem. Biophys. 269. Pp :18-24 .
15. Ronald, A. (2003).The Etiology of Urinary tract infection: traditional and emerging pathogens, Disease-a-Month, 49(2) pp:71-82.
16. Russinko, P.J., Agarwal, S., Choi. M,J,, (2003). Obstructive nephropathy secondary to sulfaquinoxaline calculi. Urology.;62:748.
17. Salem ,D. A.,& Mahmoud ,A. Z.,& Ibrahim ,Th. A.,& Abd El-Naser , M.,& Eman , E. (2000). evaluation of prolonged administration of sulfaquinoxaline on the hepatorenal performance of broiler chickens with special reference to tissue. Univ. Bull. Environ. Res. Vol. 3 No. 1:pp 2-22.
18. Shao, B.,& Dong, D.,& Wu, Y., Hu, J.,& Meng, J.,& Tu, X.,& Xu, S. (2005). Simultaneous determination of 17 sulfonamide residues in porcine meat, kidney and liver by solid-phase extraction and liquid chromatography– tandem mass spectrometry. Analytica Chimica Acta546: pp :174-181.
19. Singh, G. N., (2017). A Review on Drug Induced Hepatotoxicity and Its Management By Herbal Drugs. World J. Pharmacy an Pharmaceut. Sci. 6(8), 446–471.
20. Varagic ,V. M.,& Milosevic ,M. P. (2009). Farmakologija, Elitmedica, Beograd, , pp. 622-627.
21. Well, G.A.H.; Hebert, C.N. and Robins, B.C. (2003). Renal cysts in pigs prevalence and pathology in slaughtered pigs from a single herd. Vet. Rec. 106: 532-635 .