الملخص
أجريت هذه الدراسة على (24) أرنباً بالغاً، وهدفت إلى معرفة تأثير تراكيز مختلفة من السلفاكينوكسالين(50 100-) ملغ/كغ على نسيج الكلية عند الأرانب، استخدمت ( 4) مجموعات، حيث ضمت كل مجموعة ( 6 ) أرانب، تركت المجموعة الأولى كشاهد طبيعي، بينما جرعت المجموعات الأخرى بالسلفاكينوكسالين، قدم للمجموعة الأولى ماء وغذاء فقط ( شاهد)، في حين جرعت المجموعة الثانية من السلفاكينوكسالين بجرعة (50) ملغ/كغ، والمجموعة الثالثة جرعت بجرعة ( 100 ) ملغ/كغ من السلفاكينوكسالين، والمجموعة الرابعة جرعت بجرعة ( 100) ملغ/كغ من السلفاكينوكسالين ثم جرعت فموياً مركب بيكربونات الصوديوم لمدة يومين متتاليين بجرعة مقدارها ( 100 ) ملغ/كغ من وزن الجسم. أظهرت النتائج وجود تغيرات نسيجية تمثلت بوجود توسع بمحفظة بومان، وضمور بالكبيبات، وذلك عند الأرانب المعاملة بجرعات مختلفة من مركب السلفاكينوكسالين ( 100-50 ) ملغ/كغ وزن حي، مقارنةً مع مجموعة الشاهد .
المراجع
1. Alonso, .V, Linares, .V, Bellés, .M,. (2009). Sulfaquinoxaline induced oxidative stress: a possible mechanism of male infertility. Reprod Toxicol.;27:35–40.
2. Amine ,B.,& Tarek ,K.,& Riad , B.,& Soumia ,R.,& Ibtessem , L.,& Nadji ,B. (2020).Evaluation of Adverse Effects of Antibiotics on Broiler Chickens .J. World Poult. Res. 10(2S) pp: 145-150.
3. Bani-Asadi ,F.Z.,& Ahmadi ,M.,& Rokni ,N.,& Golestan , L.,& Shahidi ,S. A.(2021). Assessment of the Distribution and Concentration of Residual Antibiotics in Chicken Meat and Liver Samples Collected in Tehran by Liquid Chromatography and Tandem Mass Spectrometry. E JVS, 52,pp: 11-21.
4. Begent ,L.A.,& Hill ,A.R.,& Steventon ,G.B.,& Hutt ,A.J.,& Pallister ,C.J.,& Cowell ,D.C. (2001).Characterization and purification of the vitamin K .epoxide reductasessystemfrom rat liver. J. Phann. PharmacoL: pp 481-486 .
5. Chapman, H.D. (2009). A landmark contribution to poultry science prophylactic control of coccidiosis in poultry. Poult Sci 88:813–815.
6. Doustar,Y.A.,&Feizi,D.,&Mohajeri,M.H.,&Khayat-Nouri,M.H.,&Mohammad,M.H.(2008). Histopathological evaluation of the effect of Sulfamide Trimethoprim administration on renal.Islamic Azad University, Tabriz Branch, Tabriz, Iran tissue in broiler chickens .
7. Duquette, P. (2005). A US perspective on the current and future regulation of anticoccidial drugs and vaccines, Proceedings of the IXth International Coccidiosis Conference . Foz de Iguassu:Parana, Brazil, pp: 117-124.
8. Faddoul , G . P.,& Amato , S. V.,& Sevoian , M. (1966). Studies on Intolerance to Sulfaquinoxaline in Chickens University of Massachusetts, Waltham, Massachusetts . Fellows Avian Diseases, Vol. 11, No. 2. Pp. 226-240.
9. Heidari, .R, Esmailie, .N, Azarpira, .N,. (2016). Effect of thiol-reducing agents and antioxidants on sulfaquinoxaline-induced hepatic injury in normotermic recirculating isolated perfused rat Kedney. Toxicol Res. 2016;32:133–140.
10. Kannan, .K, Jain, S.K. (2000). Oxidative stress and apoptosis. Pathophysiology.;7:153–163.
11. Luna, L. G. (Ed.). (1968). Manual of histologic methods of the armed forces institute of pathology. McGraw-Hill, 36-95.
12. Mor ,F.,& Kocasari ,F. S.,& Ozdemir ,G. B. (2012). Determination of Sulfonamide residues in cattle meats by the Charm-II system and validation with high performance liquid chromatography with fluorescence detection. Food Chemistry. 134, pp: 1645-1649.
13. Odigie, B.E. (2013). Edo State Histological effects of pre-exposure prophylactic consumption of sulfa drugs on Liver and Kidney of albino Wister rats . Benin City: Journal of Pharmacy and Biological Sciences PP 14-19.
14. Preusch ,P.C.,& Hazelett ,S.E.,& Lemasters , K.K. (1989).Sulfaquinoxaline inhibition of vitamin K epoxide and quinone reductase. Arch. Biochem. Biophys. 269. Pp :18-24 .
15. Ronald, A. (2003).The Etiology of Urinary tract infection: traditional and emerging pathogens, Disease-a-Month, 49(2) pp:71-82.
16. Russinko, P.J., Agarwal, S., Choi. M,J,, (2003). Obstructive nephropathy secondary to sulfaquinoxaline calculi. Urology.;62:748.
17. Salem ,D. A.,& Mahmoud ,A. Z.,& Ibrahim ,Th. A.,& Abd El-Naser , M.,& Eman , E. (2000). evaluation of prolonged administration of sulfaquinoxaline on the hepatorenal performance of broiler chickens with special reference to tissue. Univ. Bull. Environ. Res. Vol. 3 No. 1:pp 2-22.
18. Shao, B.,& Dong, D.,& Wu, Y., Hu, J.,& Meng, J.,& Tu, X.,& Xu, S. (2005). Simultaneous determination of 17 sulfonamide residues in porcine meat, kidney and liver by solid-phase extraction and liquid chromatography– tandem mass spectrometry. Analytica Chimica Acta546: pp :174-181.
19. Singh, G. N., (2017). A Review on Drug Induced Hepatotoxicity and Its Management By Herbal Drugs. World J. Pharmacy an Pharmaceut. Sci. 6(8), 446–471.
20. Varagic ,V. M.,& Milosevic ,M. P. (2009). Farmakologija, Elitmedica, Beograd, , pp. 622-627.
21. Well, G.A.H.; Hebert, C.N. and Robins, B.C. (2003). Renal cysts in pigs prevalence and pathology in slaughtered pigs from a single herd. Vet. Rec. 106: 532-635 .
2. Amine ,B.,& Tarek ,K.,& Riad , B.,& Soumia ,R.,& Ibtessem , L.,& Nadji ,B. (2020).Evaluation of Adverse Effects of Antibiotics on Broiler Chickens .J. World Poult. Res. 10(2S) pp: 145-150.
3. Bani-Asadi ,F.Z.,& Ahmadi ,M.,& Rokni ,N.,& Golestan , L.,& Shahidi ,S. A.(2021). Assessment of the Distribution and Concentration of Residual Antibiotics in Chicken Meat and Liver Samples Collected in Tehran by Liquid Chromatography and Tandem Mass Spectrometry. E JVS, 52,pp: 11-21.
4. Begent ,L.A.,& Hill ,A.R.,& Steventon ,G.B.,& Hutt ,A.J.,& Pallister ,C.J.,& Cowell ,D.C. (2001).Characterization and purification of the vitamin K .epoxide reductasessystemfrom rat liver. J. Phann. PharmacoL: pp 481-486 .
5. Chapman, H.D. (2009). A landmark contribution to poultry science prophylactic control of coccidiosis in poultry. Poult Sci 88:813–815.
6. Doustar,Y.A.,&Feizi,D.,&Mohajeri,M.H.,&Khayat-Nouri,M.H.,&Mohammad,M.H.(2008). Histopathological evaluation of the effect of Sulfamide Trimethoprim administration on renal.Islamic Azad University, Tabriz Branch, Tabriz, Iran tissue in broiler chickens .
7. Duquette, P. (2005). A US perspective on the current and future regulation of anticoccidial drugs and vaccines, Proceedings of the IXth International Coccidiosis Conference . Foz de Iguassu:Parana, Brazil, pp: 117-124.
8. Faddoul , G . P.,& Amato , S. V.,& Sevoian , M. (1966). Studies on Intolerance to Sulfaquinoxaline in Chickens University of Massachusetts, Waltham, Massachusetts . Fellows Avian Diseases, Vol. 11, No. 2. Pp. 226-240.
9. Heidari, .R, Esmailie, .N, Azarpira, .N,. (2016). Effect of thiol-reducing agents and antioxidants on sulfaquinoxaline-induced hepatic injury in normotermic recirculating isolated perfused rat Kedney. Toxicol Res. 2016;32:133–140.
10. Kannan, .K, Jain, S.K. (2000). Oxidative stress and apoptosis. Pathophysiology.;7:153–163.
11. Luna, L. G. (Ed.). (1968). Manual of histologic methods of the armed forces institute of pathology. McGraw-Hill, 36-95.
12. Mor ,F.,& Kocasari ,F. S.,& Ozdemir ,G. B. (2012). Determination of Sulfonamide residues in cattle meats by the Charm-II system and validation with high performance liquid chromatography with fluorescence detection. Food Chemistry. 134, pp: 1645-1649.
13. Odigie, B.E. (2013). Edo State Histological effects of pre-exposure prophylactic consumption of sulfa drugs on Liver and Kidney of albino Wister rats . Benin City: Journal of Pharmacy and Biological Sciences PP 14-19.
14. Preusch ,P.C.,& Hazelett ,S.E.,& Lemasters , K.K. (1989).Sulfaquinoxaline inhibition of vitamin K epoxide and quinone reductase. Arch. Biochem. Biophys. 269. Pp :18-24 .
15. Ronald, A. (2003).The Etiology of Urinary tract infection: traditional and emerging pathogens, Disease-a-Month, 49(2) pp:71-82.
16. Russinko, P.J., Agarwal, S., Choi. M,J,, (2003). Obstructive nephropathy secondary to sulfaquinoxaline calculi. Urology.;62:748.
17. Salem ,D. A.,& Mahmoud ,A. Z.,& Ibrahim ,Th. A.,& Abd El-Naser , M.,& Eman , E. (2000). evaluation of prolonged administration of sulfaquinoxaline on the hepatorenal performance of broiler chickens with special reference to tissue. Univ. Bull. Environ. Res. Vol. 3 No. 1:pp 2-22.
18. Shao, B.,& Dong, D.,& Wu, Y., Hu, J.,& Meng, J.,& Tu, X.,& Xu, S. (2005). Simultaneous determination of 17 sulfonamide residues in porcine meat, kidney and liver by solid-phase extraction and liquid chromatography– tandem mass spectrometry. Analytica Chimica Acta546: pp :174-181.
19. Singh, G. N., (2017). A Review on Drug Induced Hepatotoxicity and Its Management By Herbal Drugs. World J. Pharmacy an Pharmaceut. Sci. 6(8), 446–471.
20. Varagic ,V. M.,& Milosevic ,M. P. (2009). Farmakologija, Elitmedica, Beograd, , pp. 622-627.
21. Well, G.A.H.; Hebert, C.N. and Robins, B.C. (2003). Renal cysts in pigs prevalence and pathology in slaughtered pigs from a single herd. Vet. Rec. 106: 532-635 .